#4360 FACTORS ASSOCIATED TO RENAL REMISSION IN CRESCENTIC GLOMERULONEPHRITIS

Abstract Background and Aims Impaired renal function is one of the most relevant factors associated to crescentic glomerulonephritis (CGN) prognosis. However, remission has not yet been defined clinicians are required use systemic scores (such as BVAS) predict severity. In this retrospective study, we aim describe long-term chronic dialysis incidence survival in CGN. Method We included all biopsy-proven CGN our center between 2004 2022. At baseline, demographics, treatments comorbidities were collected. Renal was assessed by glomerular filtration rate (GFR) using CKD-EPI equation, quantification proteinuria demonstration hematuria. During follow-up (median 1486, interquartile range [25-3082] days) vital status evaluated. Factors requirement Cox regression models. A combined endpoint death established. assessed. Results 47 (77% female, 67±15 years). Of them, 35 (75%) presented positive ANCA antibodies, 3 (6%) basement membrane (GBM) 8 (17%) GBM antibodies (2%) negative autoimmunity. Induction treatment based on prednisone cyclophosphamide 43 patients (91%), rituximab alone (2%). admission, median 11 (11-21) ml/min/1.73 m2, 1030 (552-1872) mg/g (91%) Nineteen (40%) at admission. Following definition KDIGO guidelines for remission, 28 (64%) achieve it 6 months. follow-up, fifteen (36%) started dialysis. type (dual (+) vs (+), p = 0.003), admission (p 0.001), AKIN 0.050), (p<0.001), percentage crescents 0.037), 0.046) after induction (p<0.001). Twenty-four (53%) died or needed during follow-up. 0.017), others, 0.003) (Figure 1), debut An adjusted model demonstrated that need independently achieving (i.e. months) (HR 8.78, 95%CI (2.88-26.7), p<0.001) 3.96, [1.15-13.6], 0.029). Conclusion The independent predictors